Obviously, Chief Daruma is trying to communicate to you a message to help you on your journey:
Learn It is nearly impossible to avoid all those crapshoot homing missiles, but guarding them all will ensure that you take less damage to the point where you can actually heal from time to time without dying. Fortunately, Chief Daruma is relatively weak for an area boss, and even those missiles aren't much compared to the Kamikui bosses. Stick about 10m away from Chief Daruma whenever he is not using the massive missile spam attack so that he will be less likely to use the homing missile attack again.
Also, if you use wand or staff, get out a bow or another weapon type for blocking.